Calming effect will take place within 30 to 45 minutes depending on the size of your furry friends.Active ingredients: CBD Full Spectrum (30mg per treat), Tumeric and MSM to reduce inflammation, and enhance bone & joint health.Inactive ingredients: Beef Flavoring, Citric Acid, Eggs, Whole Wheat FlourPets can enjoy Daily, or on an as-needed basis.5 treats = 100mg CBD20 mg CBD per 1 treatGive: 1/3 treat for 4-7lbs1/2 treat for 8-15lbsWhole Treat for 15lbs or greater